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    hUCB-MSCs和玻璃酸鈉治療軟骨缺損5年隨訪病例報告
    更新時間:2018-02-03  瀏覽次數:

    Abstract摘要

    Background: The treatment of articular cartilage defects is a therapeutic challenge for orthopaedic surgeons. Furthermore, large osteochondral defects needs restoration of the underlying bone for sufficient biomechanical characteristics as well as the overlying cartilage.

    背景:關節軟骨缺損的治療對骨外科來說是一項非常大的挑戰。此外,骨軟骨的再生需要軟骨下骨有足夠的類似于軟骨的生物學特性。

    Case presentation: A symptomatic large osteochondral defect in the knee joint was restored using a composite of umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) 0.5 x 107/ml and 4% hyaluronic acid (HA) hydrogel. Significant improvements in pain and function of the knee joint were identified by the evaluation at 12 months after surgery. A hyaline-like cartilage completely filled the defect and was congruent with the surrounding normal cartilage as revealed by magnetic resonance imaging (MRI), a second-look arthroscopy and histological assessment. The improved clinical outcomes maintained until 5.5 years. MRI also showed the maintenance of the restored bony and cartilaginous tissues.

    案例介紹:具有大面積膝關節軟骨缺損癥狀的病人使用人臍帶血來源間充質干細胞(0.5×107細胞/ml)和玻璃酸鈉(4%)混合物進行治療。手術后12個月評估發現膝關節的功能和疼痛情況出現顯著的改善。磁共振(MRI)、二次關節鏡和組織學評估檢查發現透明樣軟骨完全填充到缺損部位并且和周圍正常軟骨融合到了一起。如此明顯的臨床療效一直持續了5.5年。

    Conclusion: This case report suggests that the composite of allogeneic UCB-MSCs and HA hydrogel can be considered a safe and effective treatment option for large osteochondral defects of the knee.

    結論:這份病例報告表明,人臍帶血來源間充質干細胞和玻璃酸鈉混合物是一種安全、有效的治療膝關節軟骨大面積缺損的方法。

    Keywords: Knee, Large osteochondral defect, Umbilical cord blood, Mesenchymal stem cell, Hyaluronic acid

    關鍵詞:膝、大面積軟骨缺損、臍帶血、間充質干細胞、透明質酸

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